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Limb‐sparing treatment for soft tissue sarcomas: Influence of prognostic factors
Author(s) -
Rossi Carlo R.,
Foletto Mirto,
Alessio Sergio,
Menin Nicola,
D'Amore Emanuele,
Rigon Alberto,
Lise Mario
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199609)63:1<3::aid-jso2>3.0.co;2-9
Subject(s) - medicine , radiation therapy , soft tissue , multivariate analysis , univariate analysis , surgery , limb perfusion , overall survival , oncology , perfusion , radiology
At present, limb‐sparing surgery is the most appropriate and acceptable treatment available for sarcomas of the extremities, although the right balance between conservative therapy and maximum efficacy has yet to be found. A better knowledge of prognostic factors may help in planning the appropriate strategy for each case. Eighty patients underwent limb‐sparing surgery for limb sarcomas (17 had surgery alone; 19 had neo‐adjuvant hyperthermic antiblastic perfusion combined or not with postoperative radiotherapy, and 44 had adjuvant radiotherapy). Univariate and multivariate analyses were made to detect statistically significant differences between subgroups and identify the more significant subset of prognostic factors. Only microscopically positive surgical margins were related to a greater risk of local recurrence, whereas overall survival was compromised by high grade and large tumor size. © 1996 Wiley‐Liss, Inc.