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Long‐term benefits of aggressive treatment for primary colorectal cancer
Author(s) -
Klein Peter,
Allison David,
Khuder Sadik,
Walsh Arlene,
Khan Zeenat,
Smith Daniel,
Webb Thomas
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199608)62:4<258::aid-jso7>3.0.co;2-5
Subject(s) - medicine , colorectal cancer , term (time) , primary treatment , cancer , primary (astronomy) , oncology , general surgery , intensive care medicine , physics , quantum mechanics , astronomy
The long‐term follow up of 128 colorectal cancer patients is reported. Seventy‐nine percent (101/128) of the patients had curative resections: 70 patients had radical lymphadenectomies with wide removal of tumor‐adjacent nodes, and 31 patients had standard resections. The 5‐year overall survival rates for Dukes' stage B and C patients and for all rectosigmoid cancer patients significantly favored radical resection (60% vs. 38%, 57% vs. 29%, respectively, P < 0.05). Tumor‐free survival rates were also higher after radical lymphadenectomy but did not reach statistical significance. Eleven percent (14/128) of the patients required multiorgan resections, and/or preoperative radiation to render fixed cancers resectable, and these patients had a 10‐year tumor‐free survival rate of 45%, compared to zero % 5‐year survival for the 27 patients who underwent palliative procedures ( P < 0.01). These results confirm that many colorectal cancer patients will be cured with aggressive treatment and they support the need for a controlled trial for evaluation of lymphadenectomy for this disease. © 1996 Wiley‐Liss, Inc.