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Cancer of the low and middle rectum: Local and distant recurrences, and survival in 350 radically resected patients
Author(s) -
Bozzetti Federico,
Mariani Luigi,
Miceli Rosalba,
Doci Roberto,
Montalto Fabrizio,
Andreola Salvatore,
Gennari Leandro
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199607)62:3<207::aid-jso11>3.0.co;2-3
Subject(s) - medicine , rectum , abdominoperineal resection , incidence (geometry) , survival rate , surgery , stage (stratigraphy) , cancer , 5 year survival rate , overall survival , colorectal cancer , paleontology , physics , optics , biology
The purpose of this study was to compare local recurrence, distant metastases, and survival rate in 350 patients with cancer of the middle and low rectum who underwent a radical abdominoperineal resection (APER) or a sphincter‐saving resection (SSR) in our Institute. There were 257 APER patients and 93 SSR patients, with a median follow‐up of 77 months. At 5 years, the estimates in APER and SSR patients were respectively 11% and 30% for the incidence of pelvic recurrence, 18% and 8% for the incidence of distant metastases, and 64% and 73% for overall survival. In the multivariate analysis it was found that Dukes' stage significantly affected pelvic recurrences, distant metastases rate and overall survival; histologic type affected only the pelvic recurrence rate. However, the final outcome of patients following APER or SSR was similar, suggesting that local failure per se does not affect long‐term survival. © 1996 Wiley‐Liss, Inc.