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Immunohistochemical expression of Sialyl Tn, Sialyl Lewis a , Sialyl Lewis a−b− , and Sialyl Lewis x in primary tumor and metastatic lymph nodes in human gastric cancer
Author(s) -
Ikeda Yoichi,
Mori Masaki,
Kajiyama Kiyoshi,
Haraguchi Yukiaki,
Sasaki Osamu,
Sugimachi Keizo
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199607)62:3<171::aid-jso5>3.0.co;2-4
Subject(s) - immunohistochemistry , antigen , lymph , pathology , primary tumor , medicine , lesion , cancer , metastasis , immunology
Sialyl Lewis Tn(STN), Sialyl Lewis a (CA19‐9), Sialyl Lewis a−b− (DU‐PAN‐2), and Sialyl Lewis x (SLX) antigens were immunohistochemically examined in the primary tumor and metastatic lymph nodes in 35 patients with advanced gastric cancer. STN, CA 19‐9, DU‐PAN‐2, and SLX were expressed in 91%, 60%, 31%, and 60% in the primary lesion, and 77%, 54%, 22%, and 51% in the metastatic lesion, respectively. In only four cases, (11%) were all four antigens expressed in both the primary and metastatic lesions. Three antigens were expressed in 49% of primary lesions and in 20% of metastatic lesions. Compared with expression in primary lesions, increased, unchanged and decreased expressions in metastatic lesions were noted in 23%, 37%, and 40% for STN, 20%, 40%, and 40% for CA19‐9, 17%, 57%, and 26% for DU‐PAN‐2, and 26%, 31%, and 43% for SLX, respectively. These results indicate that the tumor in the primary and metastatic lesions has a heterogeneous expression of sialyl‐related antigens. However, metastases cannot be predicted based upon the expression of these antigens. © 1996 Wiley‐Liss, Inc.