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Fatal differentiated thyroid cancer
Author(s) -
Kobayashi Tetsuro,
Asakawa Hideki,
Tamaki Yasuhiro,
Umeshita Koji,
Monden Morito
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199606)62:2<123::aid-jso8>3.0.co;2-a
Subject(s) - medicine , thyroid cancer , esophagus , univariate analysis , mediastinum , multivariate analysis , thyroid , lung cancer , thyroidectomy , cancer , surgery , radiology , oncology
Thirty‐five patients who died of differentiated thyroid cancer were analyzed for factors affecting survival. The neck was the most common initial site of recurrence (62.0%). The lung was the most common metastatic site (56.7%). Major sites associated with death were locoregional recurrence (neck and mediastinum: 48.6%) and bone metastases (22.9%). By univariate analysis, local tumor extension, type of initial surgery, and residual tumor and/or existence of distant metastases at the initial operation were significant factors affecting survival. Stepwise multivariate analysis revealed that invasion of the esophagus and/or carotid artery shortened survival and that multiple surgeries extended survival. Our results suggest that to improve survival in patients with differentiated thyroid cancer, better locoregional control, including multiple surgical resection, is necessary. © 1996 Wiley‐Liss, Inc.