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Long‐term outcome after pneumonectomy for nonsmall cell lung cancer
Author(s) -
Rocco Patrick M.,
Antkowiak Joseph G.,
Takita Hiroshi,
Urschel John D.
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199604)61:4<278::aid-jso9>3.0.co;2-7
Subject(s) - pneumonectomy , medicine , lung cancer , cancer , surgery
Long‐term survivors (5 or more years) of pneumonectomy for nonsmall cell lung cancer are at risk for late death from cancer recurrence, second primary malignancies, and cardiopulmonary insufficiency related to the adverse physiological effects of pneumonectomy. A retrospective study of pneumonectomy patients was done to quantify the risks of late death from these causes. Of 246 patients treated for nonsmall cell lung cancer by pneumonectomy, medical records of 49 who survived 5 or more years were reviewed. Follow‐up for the 49 long‐term survivors ranged from 60 to 240 months, with a mean of 113 months. Twenty‐five (51%) of the long‐term survivors were alive at the time of the study. Twenty‐four (49%) had died. Causes of death included late lung cancer recurrence (6 patients), second primary malignancies (7 patients), cardiopulmonary insufficiency (4 patients), and miscellaneous causes unrelated to cancer and its treatment (7 patients). Long‐term survival after pneumonectomy for nonsmall cell lung cancer occurs in 20% of patients. Late lung cancer recurrence and second primary malignancies are important causes of death in these patients. Late cardiopulmonary insufficiency related to adverse physiological consequences of pneumonectomy is uncommon. Long‐term follow‐up is recommended after pneumonectomy for nonsmall cell lung cancer. © 1996 Wiley‐Liss, Inc.