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Suppressive effect of iodine on DMBA‐induced breast tumor growth in the rat
Author(s) -
Funahashi Hiroomi,
Imai Tsuneo,
Tanaka Yuji,
Tobinaga Junichi,
Wada Masaki,
Morita Takako,
Yamada Fumio,
Tsukamura Kyosuke,
Oiwa Mikinao,
Kikumori Toyone,
Narita Tatsuhiko,
Takagi Hiroshi
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199603)61:3<209::aid-jso9>3.0.co;2-f
Subject(s) - dmba , iodine , endocrinology , medicine , 7,12 dimethylbenz[a]anthracene , breast cancer , mammary tumor , cancer research , chemistry , cancer , carcinogenesis , organic chemistry
Concerning the suppressive effect of inorganic iodine on the growth of 7,12‐dimethyl‐benz(a)anthracene (DMBA)‐induced breast tumor in female Sprague‐Dawley (SD) rats, we previously reported that although iodine itself had a suppressive effect on the tumor growth, its effect was not as strong as that of MPA (medroxy‐progesterone acetate). However, the combined medication of iodine at a low concentration + MPA showed a stronger effect than MPA alone. The purpose of the present study is to elucidate this mechanism of action by determining the uptake of the administered iodine into breast tumor tissue. Breast tumors were induced with DMBA in female SD rats, and these animals were treated with MPA + inorganic iodine at various concentrations for 4 weeks to determine tumor growth and tumor iodine content. In the comparison of tissue iodine content in growth‐suppressive tumors with that in nonsuppressive tumors, the former showed a much higher iodine content. This suggests that direct uptake of inorganic iodine by breast tumors led to the suppression of tumor growth. © 1996 Wiley‐Liss, Inc.