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Prognostic value of BHCG and local tumor invasion in stage I seminoma of the testis
Author(s) -
Schwartz Bradley F.,
Auman Richard,
Peretsman Samuel J.,
Moul Judd W.,
Deshon George E.,
Hernandez Javier,
Rozanski Thomas A.,
Thrasher J. Brantley
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199602)61:2<131::aid-jso7>3.0.co;2-d
Subject(s) - medicine , stage (stratigraphy) , seminoma , value (mathematics) , gynecology , oncology , chemotherapy , statistics , biology , paleontology , mathematics
Approximately 10–15% of patients with stage I pure seminoma of the testis have an elevated preorchiectomy serum beta human chorionic gonadotropin level [1–4]. The prognostic significance of this elevation is unknown. We performed a multi‐institutional retrospective review of 332 men with stage I pure seminoma of the testis and evaluated the prognostic significance of this elevation and the prognostic value of local invasion of the primary tumor. Twenty‐five of 191 evaluable patients (13%) had elevated preorchiectomy beta human chorionic gonadotropin. All normalized postoperatively and are alive without evidence of disease with a median follow‐up of 50 months (range 1–124 mo). Of 191 patients, 190 (99.5%) are alive and free of disease. One patient underwent salvage chemotherapy for a chest recurrence, and he is alive and free of disease at 72 months. We conclude that elevated preorchiectomy serum beta human chorionic gonadotropin level and local invasion of the primary tumor do not portend a poor prognosis in patients with clinical stage I pure seminoma of the testis. (This is a US Government work and, as such is in the public domain in the United States of America.) © 1996 Wiley‐Liss, Inc.