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Syndrome of inappropriate antidiuretic hormone secretion in papillary serous surface carcinoma of the peritoneum
Author(s) -
Resnik Edward,
Bender David
Publication year - 1996
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/(sici)1096-9098(199601)61:1<63::aid-jso14>3.0.co;2-y
Subject(s) - medicine , carboplatin , ascites , chemotherapy , vincristine , peritoneum , antidiuretic , syndrome of inappropriate antidiuretic hormone secretion , serous fluid , ovarian carcinoma , hyponatremia , peritonitis , cyclophosphamide , surgery , hormone , oncology , ovarian cancer , cancer , cisplatin
A case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with suboptimally cytoreduced stage III papillary serous surface carcinoma of the peritoneum is described. After the primary surgery, the patient refused further therapy. Within a month bilateral pleural effusions and abdominal ascites compelled the patient to accept treatment with carboplatin and cyclophosphamide. Ten days following the chemotherapy, she was admitted in a disoriented state with serum sodium of 117‐mEq/L. During the evaluation, treatment, and subsequent follow‐up, the diagnosis of SIADH was confirmed. Numerous disease processes have been associated with the development of SIADH; however, there have been few reports in gynecologic malignancies. Possible etiology and clinical management of this patient are briefly discussed. © 1996 Wiley‐Liss, Inc.