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High prevalence of GB virus C/hepatitis G virus in Kinshasa, Democratic Republic Of Congo: A phylogenetic analysis
Author(s) -
Liu HsinFu,
MuyembeTamfum JeanJacques,
Dahan Karin,
Desmyter Jan,
Goubau Patrick
Publication year - 2000
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(200002)60:2<159::aid-jmv9>3.0.co;2-v
Subject(s) - virology , gb virus c , clade , virus , phylogenetic tree , biology , flaviviridae , genotype , phylogenetics , hepatitis c virus , viral disease , genetics , gene
A prevalence of 10.3% of GB virus C (GBV‐C)/hepatitis G virus (HGV) carriers was found in 97 pregnant women from Kinshasa, Congo (formerly Zaire), while prevalences of 1%, 4.1%, and 0% were found for hepatitis C virus, human immunodeficiency virus, and human T‐lymphotropic virus respectively. Phylogenetic analysis of the ten GBV‐C/HGV positives based on the 5′ non‐coding region using three different methods identified consistently three GBV‐C/HGV genotypes. Four main clades were found within the type 1 sequences. All the Congolese isolates are GBV‐C/HGV type 1 in two different clades. The clustering of seven Congolese isolates was inconsistent in different methods. Further likelihood‐mapping analysis showed a well‐resolved phylogeny, confirming the clustering of the seven Congolese isolates with a Belgian strain representing a new clade in the GBV‐C/HGV type 1 sequences. J. Med Virol. 60:159–165, 2000. © 2000 Wiley‐Liss, Inc.