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High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions
Author(s) -
Chan Paul K.S.,
Li WaiHon,
Chan May Y.M.,
Ma WeiLing,
Cheung Jo L.K.,
Cheng Augustine F.
Publication year - 1999
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199910)59:2<232::aid-jmv18>3.0.co;2-7
Subject(s) - medicine , odds ratio , cervical intraepithelial neoplasia , cervical cancer , hpv infection , genotype , cytology , squamous intraepithelial lesion , papanicolaou stain , gastroenterology , confidence interval , gynecology , cancer , pathology , biology , biochemistry , gene
The prevalence of human papillomavirus (HPV) among 332 Hong Kong Chinese women with abnormal Papanicolaou smears were determined by polymerase chain reaction and restriction fragment length polymorphism analysis. The overall HPV positive rate was 44.3% with 18.6% (16/86) for normal/inflamed cervices, 36.4% (32/88) for condyloma, 64.7% (33/51) for cervical intraepithelial neoplasia grade 1 (CIN 1), 37.9% (11/29) for CIN 2, 68.3 (41/60) for CIN 3, and 77.8% (14/18) for carcinoma. Double HPV infection was detected in 17 of the 147 positive samples, with a significantly higher proportion in patients with normal or inflamed cervices than those with CIN or carcinoma (31.3% vs 10.5%, P = .029). The six most commonly identified genotypes were HPV 16 (33.3%), HPV 58 (23.8%), HPV 11, 18, 31 (8.8% each), and HPV 33 (6.8%). The worldwide uncommon genotype HPV 58 was found to be the second most common genotype detected in patients with cervical carcinoma (6 of 18 patients). HPV 58 infection showed a significant association with CIN/carcinoma (odds ratio [OR] = 3.98; 95% confidence interval [CI] = 1.22–14.35) and a significant trend of increase in prevalence with increasing severity of cervical lesion (χ 2 = 5.84; P = .016). Among Hong Kong Chinese women with abnormal cervical cytology, the detection of HPV 58 carried a positive predictive value of 68.6% for a cervical lesion of CIN 1 or higher severity. The high prevalence of HPV 58 among Chinese women, particularly in patients with carcinoma, has an implication on the design of HPV detection methods and the development of vaccines. J. Med. Virol. 59:232–238, 1999. © 1999 Wiley‐Liss, Inc.