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Poliovirus infection induces apoptosis in CaCo‐2 cells
Author(s) -
Ammendolia Maria Grazia,
Tinari Antonella,
Calcabrini Annarica,
Superti Fabiana
Publication year - 1999
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199909)59:1<122::aid-jmv20>3.0.co;2-9
Subject(s) - enterocyte , poliovirus , apoptosis , cell culture , virology , biology , agarose gel electrophoresis , microbiology and biotechnology , flow cytometry , dna , virus , genetics , small intestine , biochemistry
The effects of poliovirus infection in CaCo‐2 cells, a human enterocyte‐like cell line are described. Infected cells were examined by a combination of techniques, including optical and electron microscopy, cytofluorimetric analysis of DNA content, and DNA agarose gel electrophoresis. Results obtained by the different experimental approaches demonstrate that poliovirus infection in enterocyte‐like cells can result in an apoptotic process. J. Med. Virol. 59:122–129, 1999. © 1999 Wiley‐Liss, Inc.