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A two dose combined hepatitis A and B vaccine in Chinese youngsters
Author(s) -
Lee ShouDong,
Chan ChoYu,
Yu MayIng,
Wang YuanJen,
Chang FullYoung,
Lo KwangJuei,
Safary Assad
Publication year - 1999
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199909)59:1<1::aid-jmv1>3.0.co;2-f
Subject(s) - virology , medicine , hepatitis b , hepatitis b vaccine , hepatitis b virus , virus , hbsag
This open, randomized study was conducted in healthy Chinese youngsters, aged between 10 and 19 years to compare the reactogenicity and immunogenicity of two vaccines: the combined vaccine against hepatitis A and B was administered in a two‐dose schedule with the profile of the corresponding monovalent vaccines, while the concomitant vaccine was administered also on a two‐dose schedule but simultaneously in opposite arms. All vaccinees had antibodies against hepatitis A (anti‐HAV) after the 2‐dose administration, whereas all but four in the first and two in the second group had protective titres against hepatitis B (anti‐HBs). At month 7, the geometric mean titres for both antibodies were more than double for the group of subjects receiving the combined vaccine: 3,701 vs. 1,705 mIU/ml for the anti‐HAV, and 1,524 vs. 720 mIU/ml for the anti‐HBs response. Injection site pain was the most commonly reported local symptom and headache was the most reported general symptom. It is concluded that this combined vaccine against hepatitis A and B, administered according to a two‐dose schedule, is well‐tolerated and highly immunogenic. J. Med. Virol. 59:1–4, 1999. © 1999 Wiley‐Liss, Inc.