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A new genotype of TT virus (TTV) infection among Colombian native Indians
Author(s) -
Tanaka Yasuhito,
Mizokami Masashi,
Orito Etsuro,
Nakano Tatsunori,
Kato Takanobu,
Ding Xin,
Ohno Tomoyoshi,
Ueda Ryuzo,
Sonoda Shunro,
Tajima Kazuo,
Miura Tomoyuki,
Hayami Masanori
Publication year - 1999
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199903)57:3<264::aid-jmv9>3.0.co;2-d
Subject(s) - virology , genotype , biology , virus , phylogenetic tree , population , dna virus , genetics , medicine , genome , gene , environmental health
Serum TTV DNA was assayed in 140 native Indians and 40 members of the general population in Colombia to determine the prevalence of TT virus (TTV) infection among Colombian native Indians. Of the 140 native Indians, 23 (16.4%) were positive for TTV DNA, compared to 4 (10.0%) of 40 from the general population ( P = not significant). The prevalence of TTV DNA among native Indians was much higher than that of HBsAg and anti‐HCV. Comparison of subjects with and without TTV DNA revealed no significant differences in all characteristics between the two groups. A phylogenetic tree, using the open reading frame 1 sequence (222 bp), indicated that the virus could be classified into four different genotypes, including three previously reported ones. The results show that TTV infection is common in Colombian native Indians without liver disease and also indicate the existence of a novel genotype of TTV. J. Med. Virol. 57:264–268, 1999. © 1999 Wiley‐Liss, Inc.