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Severe exacerbation of liver disease during pregnancy in a thalassemic GBV‐C/HGV–positive patient and neonatal hepatitis in offspring
Author(s) -
Horsmans Y.,
Karayiannis P.,
Christophe J.L.,
Pickering J.M.,
Debauche C.,
Cornu C.,
Rahier J.,
Hess G.,
Thomas H.C.,
Geubel A.P.
Publication year - 1999
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199902)57:2<122::aid-jmv6>3.0.co;2-2
Subject(s) - offspring , neonatal hepatitis , medicine , exacerbation , virology , pregnancy , liver disease , disease , hepatitis , pediatrics , immunology , biology , genetics , biliary atresia , transplantation , liver transplantation
The case of a young woman with GB virus C/hepatitis G virus (GBV‐C/HGV) infection and with a severe exacerbation of chronic hepatitis of unknown etiology during pregnancy is described. In the offspring, severe neonatal hepatitis with subsequent mild chronic liver disease of at least 16‐month duration was followed by the development of antibodies to the envelope protein (E2) of GBV‐C/HGV, suggesting that the child was recovering from GBV‐C/HGV infection. There was an improvement in clinical and biochemical parameters in the mother following delivery and alpha‐interferon therapy was associated with a transient biochemical response. J. Med. Virol. 57:122–125, 1999. © 1999 Wiley‐Liss, Inc.