Premium
Prevalence of papillomavirus, Epstein‐Barr virus, cytomegalovirus, and herpes simplex virus type 2 in urinary bladder cancer
Author(s) -
Gazzaniga Paola,
Vercillo Roberta,
Gradilone Angela,
Silvestri Ida,
Gandini Orietta,
Napolitano Maria,
Giuliani Laura,
Fioravanti Alessandro,
Gallucci Michele,
Aglianò Anna Maria
Publication year - 1998
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199808)55:4<262::aid-jmv2>3.0.co;2-z
Subject(s) - virology , cytomegalovirus , herpes simplex virus , herpesviridae , virus , epstein–barr virus , biology , viral disease , bladder cancer , immunology , cancer , genetics
Recent epidemiological studies suggest that the risk for urological malignancies may be related to the exposure to infectious agents. Human Papillomaviruses type 16 and 18 (HPV 16, HPV 18), Epstein‐Barr virus (EBV), cytomegalovirus (CMV) and herpes simplex virus type 2 (HSV‐2) have been suggested previously as cofactors in the pathogenesis of some malignancies in humans. The present paper, the presence of HPV 16, HPV 18, EBV, CMV and HSV‐2 genomes was investigated in a panel of 35 biopsies from urinary bladder carcinomas using the polymerase chain reaction (PCR). Sequences of EBV, HPV, CMV and HSV‐2 genomes were detected in 34%, 31%, 11% and 9% of tissue samples respectively, while in 20% of patients we found more than one viral infection. Absence of viral genomes was found in normal bladder. To our knowledge, this is the first report concerning the association of EBV, CMV and HSV‐2 with bladder cancer. This finding may raise the question whether such viral infection may contribute to development and progression of some types of urological malignancies in humans. J. Med. Virol. 55:262–267, 1998 . © 1998 Wiley‐Liss, Inc.