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Hepatitis C virus genotypes implicated in mixed cryoglobulinemia
Author(s) -
Nguyen Quang Tri,
LeruezVille Marianne,
Ferrière Françoise,
Cohen Pascal,
RoulotMarullo Dominique,
Coste Thierry,
Dény Paul,
Guillevin Loïc
Publication year - 1998
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199801)54:1<20::aid-jmv4>3.0.co;2-r
Subject(s) - cryoglobulinemia , genotyping , genotype , hepatitis c virus , virology , flaviviridae , polymerase chain reaction , virus , hepatitis c , hepacivirus , viral disease , medicine , immunology , biology , genetics , gene
Recent reports suggest that hepatitis C virus (HCV) might be a causative agent of mixed cryoglobulinemia. To determine whether the HCV genotype is a factor implicated in the onset of cryoglobulinemia, genotyping by direct sequencing of polymerase chain reaction products of the 5′ non coding region was carried out among 45 HCV‐infected patients. Genotypes 1 and 2 were found more prevalent in symptomatic cryoglobulinemia patients. Due to the presence of genotypes 4 and 5 found in this panel of French patients (9.3%), HCV genotyping based on sequence determination is recommended. J. Med. Virol. 54:20–25, 1998. © 1998 Wiley‐Liss, Inc.