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Antibodies against enteroviruses in intravenous Ig preparations: Great variation in titres and poor correlation with the incidence of circulating serotypes
Author(s) -
Galama Jochem M. D.,
Vogels Maria T. E.,
Jansen Gerco H.,
Gielen Marij,
Heessen Frans W. A.
Publication year - 1997
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199711)53:3<273::aid-jmv16>3.0.co;2-i
Subject(s) - serotype , antibody , enterovirus , virology , titer , biology , incidence (geometry) , virus , neutralizing antibody , microbiology and biotechnology , immunology , mathematics , geometry
Antibody titres in immunoglobulin preparations for intravenous use were tested against 24 different enterovirus serotypes and varied between 1 : 100 and 1 : 10,000 within a single batch. Differences up to 8‐fold were found for homologous titres between two different batches that were prepared 6 years apart. The lowest titre obtained was 1 : 40. The observed differences within and between the two batches could not be explained by different incidence of serotypes of enteroviruses circulating at the time blood was collected. Differences in titres of up to 18‐fold were observed when several strains of the same serotype were tested suggesting that intratypic variation influences antibody titres. It is concluded that immunoglobulin preparations contain antibodies against many enteroviruses, but that titres can be low and cannot be predicted from the incidence of any particular serotype circulating in the community. Because of intratypic variation, selection of a batch for specific treatment should be based on results obtained with the patient's own isolate, and not with a reference strain. J. Med. Virol. 53:273–276, 1997. © 1997 Wiley‐Liss, Inc.