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Incidence of JC viruria is higher than that of BK viruria in Taiwan
Author(s) -
Tsai RongTai,
Wang Meilin,
Ou WeiChih,
Lee YaoLing,
Li ShuanYow,
Fung ChiungYau,
Huang YihLeh,
Tzeng TsairYuh,
Chen Yueh,
Chang Deching
Publication year - 1997
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199707)52:3<253::aid-jmv3>3.0.co;2-1
Subject(s) - virology , bk virus , incidence (geometry) , polymerase chain reaction , genotype , urine , population , jc virus , biology , immunology , medicine , virus , progressive multifocal leukoencephalopathy , transplantation , gene , kidney transplantation , genetics , physics , environmental health , optics
Abstract To investigate the prevalence of human polyomaviruses in Taiwan, urine samples from immunocompetent (healthy), transient immunocompromised (pregnant), and prolonged immunosuppressed (autoimmune disease) individuals were collected throughout the island. The viral DNA in the urine was detected by the polymerase chain reaction (PCR) and Southern blot. The viral genotypes were determined by DNA sequencing within the regulatory region. The overall results, including cases reported previously, show that 13.3% (10/75) of immunocompetent individuals, 26.0% (20/77) of pregnant women, and 37.5% (18/48) of autoimmune disease patients are JCV positive. All of the immunocompetent individuals are BKV negative, but 3.9% (3/77) of the pregnant women and 6.2% (3/48) of autoimmune disease patients are BKV positive. Twenty‐four percent (48/200) of the examined urine samples were JCV positive, but only 3% (6/200) were BKV positive. JCV positive individuals were mainly infected with CY (42%) and TW‐1 (52%) subtypes. These results suggest that the incidence of urinary excretion of human polyomaviruses in immunosuppressed individuals is higher than that of immunocompetent individuals. The prevalence of JCV appears to be higher than that of BKV in Taiwan. In addition, CY and TW‐1 are the predominant subtypes of JCV prevalent in the Taiwanese population. J. Med. Virol. 52:253–257, 1997. © 1997 Wiley‐Liss, Inc.