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Prevalence and molecular epidemiology of GB virus C/hepatitis G virus infection in Mongolia
Author(s) -
Kondo Yutaka,
Mizokami Masashi,
Nakano Tatsunori,
Kato Takanobu,
Ueda Ryuzo,
Mukaide Motokazu,
Hikiji Kazumasa,
Ishida Takafumi,
Dorjsuren Dorjibal,
Dashnyam Bumbein,
Oyunsuren Tsendsuren
Publication year - 1997
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199706)52:2<143::aid-jmv4>3.0.co;2-3
Subject(s) - virology , virus , molecular epidemiology , epidemiology , hepatitis a virus , biology , hepatitis c virus , hepatitis b virus , viral disease , medicine , genotype , gene , genetics
We studied the prevalence of GB virus C/hepatitis G virus (GBV‐C/HGV) infection among 112 patients with liver disease and 121 blood donors in Ulaanbaatar, Mongolia. Reverse transcription and polymerase chain reaction were employed to detect GBV‐C/HGV RNA using the specific primers derived from the 5′‐untranslated region (5′‐UTR) of the GBV‐C/HGV genome. Nucleotide sequences of all positive samples for GBV‐C/HGV RNA were determined. The sequences were analyzed by a molecular evolutionary method. Twenty‐five (10.7%) of 233 people were positive for GBV‐C/HGV RNA. Eight (6.6%), 11 (9.1%), and 30 (24.8%) blood donors were positive for GBV‐C/HGV RNA, HBsAg, and anti‐HCV, respectively, although 17 (15.2%), 65 (58.0%), and 64 (54.5%) patients with liver disease were positive for each viral marker. The prevalences of GBV‐C/HGV RNA, HBV, and HCV in the patients were significantly higher than those in blood donors ( P < 0.05). There was no significant difference in the prevalence of anti‐HCV among people with and without GBV‐C/HGV RNA, while the prevalence of HBsAg among people with GBV‐C/HGV RNA was significantly higher than among those without GBV‐C/HGV RNA ( P < 0.05). The molecular evolutionary tree showed that GBV‐C/HGV was a heterogeneous virus and all strains could be divided into 2 types. One is the same phylogenetic type as HGV, and the other is a new type that is different from GBV‐C and HGV. J. Med. Virol. 52:143–148, 1997. © 1997 Wiley‐Liss, Inc.