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Varicella in chimpanzees
Author(s) -
Cohen Jeffrey I.,
Moskal Thomas,
Shapiro Max,
Purcell Robert H.
Publication year - 1996
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199612)50:4<289::aid-jmv2>3.0.co;2-4
Subject(s) - virology , polymerase chain reaction , virus , biology , inoculation , dermatome , virulence , herpesviridae , rash , peripheral blood mononuclear cell , varicella zoster virus , chickenpox , viral disease , gene , immunology , medicine , in vitro , genetics , neuroscience
Two chimpanzees were inoculated subcutaneously with the wild‐type Oka strain of varicella‐zoster virus (VZV). Viral DNA was detected in peripheral blood mononuclear cells of both animals using the polymerase chain reaction (PCR) shortly after inoculation. Ten days after inoculation both animals developed an erythematous, papular rash near the site of inoculation that extended into the adjacent dermatome. Viral DNA was found by PCR in a skin biopsy from one of the animals at the time of the rash. While only two animals were studied, the development of a mild form of varicella in chimpanzees indicates that these animals might be useful for molecular studies of viral genes involved in virulence or attenuation of VZV. © 1996 Wiley‐Liss, Inc.