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Immune responses to inactivated vaccine in people naturally infected with hantaviruses
Author(s) -
Qunying Lu,
Zhiyong Zhu,
Jingqing Weng
Publication year - 1996
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199608)49:4<333::aid-jmv13>3.0.co;2-b
Subject(s) - hantaan virus , virology , antibody , hemagglutination assay , biology , virus , neutralization , titer , immunization , inactivated vaccine , hemagglutination , antibody titer , vaccination , immune system , hantavirus , immunology
An inactivated Hantaan virus vaccine for hemorrhagic fever with renal syndrome (HFRS) was given by injection to 15 people who were naturally infected with either Hantaan or Seoul viruses. Immunofluorescent antibody (IFA), reversed passive hemagglutination inhibition (RPHI), hemagglutination inhibition (HI), and neutralization antibody (NA) assays were used to measure the antibody titers of the vaccinated people before and after three doses of vaccine. The results indicated that IFA and RPHI antibody titers were boosted significantly ( P < 0.05) after the vaccination. Either Hantaan or Seoul virus could induce two‐way cross‐reactive neutralization antibody responses in humans. After HTNV vaccine immunization, the NA titers of people with natural infection increased significantly ( P < 0.05) to both Hantaan and Seoul viruses, while the relative dominance between these two type responses was still similar to that of natural infection. It is worthwhile to studying the procedure further to inoculate two different virus vaccines for improving the cross‐protective effect. © 1996 Wiley‐Liss, Inc.