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Comparison of the association with eczema herpeticum in the two predominant genotypes of herpes simplex virus type 1
Author(s) -
Umene Kenichi,
Yoshida Masami,
Sakaoka Hiroshi
Publication year - 1996
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/(sici)1096-9071(199608)49:4<329::aid-jmv12>3.0.co;2-5
Subject(s) - virology , herpes simplex virus , genotype , biology , medicine , virus , genetics , gene
Eczema herpeticum, sometimes called Kaposi's varicelliform eruption, is usually caused by a disseminated herpes simplex virus infection in a patient whose underlying skin disease is atopic dermatitis. Herpes simplex virus type 1 (HSV‐1), a widespread infectious agent in human populations, is the etiologic agent of eczema herpeticum. Analyses of restriction fragment length polymorphism (RFLP) of HSV‐1 strains isolated in Japan, using restriction endonucleases, revealed the presence of two predominant genotypes of F1 and F35. The number of HSV‐1 strains of F1 genotype was over twice that of the F35 genotype, and the nucleotide change between F1 and F35 was estimated to be 1.5%. The question of whether the genomic difference between two predominant genotypes could influence clinical manifestations remained to be addressed. On the basis of RFLP, we determined genotypes of HSV‐1 strains isolated from the patients in Japan, including those with eczema herpeticum. Two of four HSV‐1 strains of F35 genotype were from patients with eczema herpeticum, whereas none of 12 HSV‐1 strains of F1 genotype was from those with eczema herpeticum. Thus, the F35 genotype seemed to be associated more frequently with eczema herpeticum than the F1 genotype. © 1996 Wiley‐Liss, Inc.