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Two cases of chronic graft‐versus‐host disease with elevated levels of soluble Fas ligand in serum
Author(s) -
Takada Satoru,
Hatsumi Nahoko,
Saito Takayuki,
Matsushima Takahumi,
Sakura Toru,
Tamura Junich,
Karasawa Masamitu,
Miyawaki Shuichi
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(200006)64:2<133::aid-ajh12>3.0.co;2-z
Subject(s) - fas ligand , pathogenesis , immunology , medicine , graft versus host disease , disease , fas receptor , apoptosis , biology , programmed cell death , biochemistry
It has recently been shown that the Fas–Fas ligand (FasL) system may be one of the pathogeneses for acute graft‐versus‐host disease (GVHD), and it has been reported that serum soluble Fas ligand (sFasL) increases with the presence of acute GVHD. However, there is no report on a correlation between the Fas–FasL system and chronic GVHD. We present two cases of chronic GVHD with elevated levels of serum sFasL. Its level in each case was high at the onset of chronic GVHD, but it decreased with steroid therapy. Liver dysfunction also improved as the level of serum sFasL decreased. It appears in these cases that the Fas–FasL system was related to the pathogenesis of liver damage. Am. J. Hematol. 64:133–136, 2000. © 2000 Wiley‐Liss, Inc.