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Multiple myeloma presenting high fever and high serum levels of lactic dehydrogenase, CRP, and interleukin‐6
Author(s) -
Murakami Hirokazu,
Takada Satoru,
Hatsumi Nahoko,
Yokohama Akihiko,
Saitoh Takayuki,
Uchiumi Hideki,
Maehara Tadashi,
Matsushima Takafumi,
Tsukamoto Norifumi,
Morita Kimio,
Tamura Jun'ichi,
Sawamura Morio,
Karasawa Masamitsu
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(200005)64:1<76::aid-ajh15>3.0.co;2-o
Subject(s) - fulminant , multiple myeloma , medicine , interleukin 6 , lactic dehydrogenase , interleukin , gastroenterology , immunology , cytokine , biology , enzyme , biochemistry
Two myeloma patients presented high fever with no signs or data indicating infection at diagnosis or relapse. Both patients had plasmablastic myeloma, and serum levels of lactic dehydrogenase (LDH) and CRP were extremely high. Plasmablastic morphology, high LDH, and CRP were recognized as poor prognostic factors, indicating a fulminant phase of multiple myeloma. Interleukin‐6 (IL‐6) was only high in measured cytokines. We proposed that IL‐6 caused high fever and induced the fulminant phase in these 2 cases. Am. J. Hematol. 64:76–77, 2000. © 2000 Wiley‐Liss, Inc.