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Folate sufficient subjects do not accumulate additional folates during supplementation
Author(s) -
SanthoshKumar C.R.,
Bisping James S.,
Kick Steven D.,
Deutsch John C.,
Kolhouse J. Fred
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(200005)64:1<71::aid-ajh13>3.0.co;2-z
Subject(s) - folic acid , quartile , placebo , medicine , folic acid supplementation , allowance (engineering) , reference daily intake , physiology , endocrinology , environmental health , pathology , confidence interval , mechanical engineering , alternative medicine , engineering
In a double‐blinded placebo‐controlled trial of folic acid supplementation in 82 alcoholic subjects, it was found that whole blood folate levels, determined by a mass spectrometric method, do not increase in subjects whose baseline folate levels are above the third quartile (folate sufficiency). Since a state of folate sufficiency can now be identified, a recommended daily allowance (RDA) for folate can be determined using objective means. Am. J. Hematol. 64:71–72, 2000. © 2000 Wiley‐Liss, Inc.