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Strong inverse correlation between serum TPO level and platelet count in essential thrombocythemia
Author(s) -
Tomita Naoto,
Motomura Shigeki,
Sakai Rika,
Fujimaki Katsumichi,
Tanabe Juichi,
Fukawa Hitoshi,
Harano Hiroshi,
Kanamori Heiwa,
Ogawa Kouji,
Mohri Hiroshi,
Maruta Atsuo,
Kodama Fumio,
Ishigatsubo Yoshiaki,
Tahara Tomoyuki,
Kato Takashi
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(200003)63:3<131::aid-ajh4>3.0.co;2-#
Subject(s) - essential thrombocythemia , platelet , medicine , plateletpheresis , correlation , immunology , gastroenterology , mathematics , apheresis , geometry
Serum thrombopoietin (TPO) levels in 50 essential thrombocythemia (ET) patients were measured using a highly sensitive sandwich ELISA. In nine cases, TPO levels were measured at two points with different platelet counts. ET patients showed significantly higher serum TPO levels ( n = 59, 2.70 ± 2.74 fmol/mL, P < 0.0001) than those of normal individuals ( n = 29, 0.83 ± 0.36 fmol/mL). Twenty‐three previously untreated ET patients also showed significantly higher serum TPO levels (1.33 ± 0.75 fmol/mL, P = 0.0066) than normal individuals. Extremely high serum TPO levels (5.46 ± 3.68 fmol/mL) were observed in ET patients with normal platelet counts. Furthermore, a strong inverse correlation was found between serum TPO levels and platelet counts in ET patients ( R = −0.729, P < 0.0001). This inverse correlation also held for each of nine cases with two‐point TPO measurements. In the clinical course of ET, megakaryocyte mass may parallel the platelet mass before and after chemotherapy. Although it is unknown whether overproduction of TPO exists or not in ET, total platelet and megakaryocyte mass, i.e., the total number of c‐Mpl, may play a role to regulate serum TPO levels. Am. J. Hematol. 63:131–135, 2000. © 2000 Wiley‐Liss, Inc.