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Analysis of HLA‐DRB1 alleles in Japanese patients with chronic myelogenous leukemia
Author(s) -
Yasukawa Masaki,
Ohminami Hideki,
Kojima Kensuke,
Inokuchi Koiti,
Nishimura Yasuharu,
Fujita Shigeru
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(200002)63:2<99::aid-ajh8>3.0.co;2-#
Subject(s) - chronic myelogenous leukemia , allele , medicine , human leukocyte antigen , leukemia , immunology , genetics , biology , antigen , gene
To clarify the association between HLA‐DRB1 alleles and chronic myelogenous leukemia (CML), the HLA‐DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA‐DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA‐DRB1*1201 was high in comparison with the healthy individuals. The frequencies of HLA‐DRB1*0403, DRB1*0802, DRB1*1403, and DRB1*1405 were high, and those of HLA‐DRB1*08032 and DRB1*1501 were low in the patients with b3a2 CML. The present results suggest positive and negative associations between certain HLA‐DRB1 alleles and CML. Am. J. Hematol. 63:99–101, 2000. © 2000 Wiley‐Liss, Inc.