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PCR‐based diagnosis of the Filipino (−− FIL ) and Thai (−− THAI ) α‐thalassemia‐1 deletions
Author(s) -
Eng Barry,
Patterson Margaret,
Borys Susan,
Chui David H.K.,
Waye John S.
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(200001)63:1<54::aid-ajh12>3.0.co;2-b
Subject(s) - thalassemia , medicine , beta thalassemia , genetics , biology
In southeast Asia, the carrier frequency of two‐gene α‐thalassemia deletions is quite high, ranging from 4% to 14% depending on the population. The most common α‐thalassemia‐1 deletion is the so‐called southeast Asian deletion (−− SEA ). In addition, a significant proportion of cases involve two other deletions, the Filipino (−− FIL ) and Thai (−− THAI ) deletions. In this report, we identify the deletion breakpoints for the (−− FIL ) and (−− THAI ) deletions, and describe PCR‐based protocols for rapid and reliable DNA diagnosis of these deletions. Am. J. Hematol. 63:54–56, 2000. © 2000 Wiley‐Liss, Inc.