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Long‐term remission in an elderly patient with mantle cell leukemia treated with low‐dose cyclophosphamide
Author(s) -
Asou Norio,
Suzushima Hitoshi,
Nishimura Shintaro,
Okubo Toshiya,
Yamasaki Hiroshi,
Osato Motomi,
Hoshino Koyu,
Takatsuki Kiyoshi,
Mitsuya Hiroaki
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(200001)63:1<35::aid-ajh8>3.0.co;2-l
Subject(s) - mantle cell lymphoma , cyclophosphamide , medicine , lymphocytosis , leukemia , chronic lymphocytic leukemia , lymphoma , gastroenterology , chemotherapy
We present an elderly patient with mantle cell leukemia who was successfully treated with low‐dose cyclophosphamide (CY). A 76‐year‐old female was diagnosed as mantle cell leukemia based on abnormal lymphocytosis and splenomegaly without lymphadenopathy. She was orally treated with 50 mg of CY daily and had continuous remission over 4 years. Rearrangements of BCL1 and immunoglobulin heavy chain genes in the peripheral blood lymphocytes were detected at diagnosis, but not 1 or 4 years later. Further studies are required to confirm the role of low‐dose CY therapy for patients with mantle cell leukemia and lymphoma. Am. J. Hematol. 63:35–37, 2000. © 2000 Wiley‐Liss, Inc.