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Haemorrhagic cystitis associated with adenovirus in a patient with AIDS treated for a non‐Hodgkin's lymphoma
Author(s) -
Ghez David,
Oksenhendler Eric,
Scieux Catherine,
Lassoued Kaïss
Publication year - 2000
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(200001)63:1<32::aid-ajh7>3.0.co;2-x
Subject(s) - hemorrhagic cystitis , medicine , bk virus , immunosuppression , lymphoma , immunology , virus , virology , genitourinary system , chemotherapy , urinary system , pathology , cyclophosphamide , kidney , kidney transplantation
Adenovirus‐induced haemorrhagic cystitis has been reported chiefly in bone marrow or kidney transplant recipients. We report hereon an HIV‐positive patient treated for a Burkitt's lymphoma who developed gross haematuria associated with fever and burning urination. Usual causes of haematuria were ruled out: lithiasis, urinary tract lesions, glomerulonephritis, mycobacterium and schistosoma infections, and drug toxicity. Adenovirus was detected by cellular cultures and BK/JC virus DNA sequences were detected using a polymerase chain reaction method. Because BK/JC virus shedding is very common (75%) in HIV patients receiving chemotherapy, our data strongly suggest that adenovirus was responsible for the haemorrhagic cystitis in our patient. In conclusion, adenovirus should be considered as a potential cause of haemorrhagic cystitis in AIDS patients whose immunosuppression is aggravated by cytotoxic drugs. Am. J. Hematol. 63:32–34, 2000. © 2000 Wiley‐Liss, Inc.