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Portal, mesenteric, and splenic vein thromboses after splenectomy in a patient with chronic myeloid leukemia variant with thrombocythemic onset
Author(s) -
Lee Je Jung,
Kim Hyeoung Joon,
Chung Ik Joo,
Park Moo Rim,
Seo Kang Seok,
Jeong Yong Yeon,
Kim Jae Kyu
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199907)61:3<212::aid-ajh10>3.0.co;2-l
Subject(s) - medicine , splenectomy , splenic artery , portal vein thrombosis , surgery , superior mesenteric vein , splenic vein , thrombosis , thrombocytosis , superior mesenteric artery , radiology , myeloid leukemia , mesenteric vein , portal hypertension , gastroenterology , spleen , platelet , portal vein , cirrhosis
Portal, mesenteric, or splenic vein thrombosis is a very uncommon complication with significant mortality in the patients undergoing splenectomy for hematologic disorders. We report a 49‐year‐old woman who developed portal, superior mesenteric, and splenic vein thromboses after splenectomy. Four years before the event, she presented with a marked thrombocytosis and was diagnosed to have chronic myeloid leukemia variant with thrombocythemic onset as evidence by Philadelphia (Ph 1 ) chromosome and a b3a2 BCR/ABL transcript. Six weeks after splenectomy, she developed severe epigastric pain. The diagnosis of thromboses of portal, mesenteric, and splenic veins was made by computed tomography scan and Doppler sonogram. She was successfully treated with antegrade intraarterial urokinase therapy via superior mesenteric artery and long‐term anticoagulant therapies. To our knowledge, our patient is the first case of portal, mesenteric, and splenic vein thromboses after splenectomy in a patient with CML variant with thrombocythemic onset successfully treated with antegrade intraarterial thrombolytic therapy followed by anticoagulant therapies. Am. J. Hematol. 61:212–215, 1999. © 1999 Wiley‐Liss, Inc.