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Risk factors for thrombosis in nonembolic cerebrovascular disease
Author(s) -
Mohanty Sujata,
Saxena Renu,
Behari Madhuri
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199903)60:3<239::aid-ajh14>3.0.co;2-9
Subject(s) - medicine , thrombosis , cardiology , stroke (engine) , mechanical engineering , engineering
Thirty‐seven young patients (less than 42 years of age) presenting with sudden onset of idiopathic nonembolic cerebrovascular disease were evaluated for underlying prothrombotic factors. Activated protein C resistance (APC‐R) was measured by Dahlback's method and the modified method using factor V‐deficient plasma. Activities of antithrombin (AT) III, protein C and S were measured. Anticardiolipin antibody was estimated by ELISA and lupus anticoagulant by kaolin clotting tests. APC‐R was the most common defect (21.62%) followed by AT III deficiency and presence of anticardiolipin antibodies (5.6% each). The latter two were present together in one case. It is thus concluded that APC‐R is the most common defect underlying idiopathic nonembolic cerebrovascular infarction in young individuals. Am. J. Hematol. 60:239–241, 1999. © 1999 Wiley‐Liss, Inc.