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Serum macrophage colony‐stimulating factor (M‐CSF) level is elevated in patients with old cerebral infarction related to vascular damage
Author(s) -
Suehiro Akira,
Tsujioka Hiroshi,
Yoshimoto Hiroshi,
Higasa Satoshi,
Kakishita Eizo
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199903)60:3<185::aid-ajh3>3.0.co;2-q
Subject(s) - medicine , von willebrand factor , thrombomodulin , endocrinology , cerebral infarction , d dimer , fibrinogen , antithrombin , stroke (engine) , plasmin , gastroenterology , thrombin , platelet , chemistry , ischemia , heparin , mechanical engineering , engineering , biochemistry , enzyme
We measured the serum levels of macrophage colony‐stimulating factor (M‐CSF) in 37 patients with an old cerebral infarction who had been surmised to have a damaged vessel wall and who had been in a stable condition for over three months after stroke onset, and those of 41 healthy control subjects. The M‐CSF levels in the patients were significantly higher ( P < 0.01) than those of the controls at 1320.4 ± 410.6 unit/ml and 853.9 ± 180.3 unit/ml, respectively. The plasma levels of von Willebrand factor (vWF) antigen ( P < 0.01) and thrombomodulin (TM) ( P < 0.05), as well as those of thrombin‐antithrombin III (TAT) complex ( P < 0.05), prothrombin fragment 1+2 (F1+2) ( P < 0.02), D‐dimer products of crosslinked fibrin degradation products (D‐dimer) ( P < 0.01), and plasmin‐antiplasmin (PAP) complex ( P < 0.05) in the patients were also significantly higher than those in the controls. Significant positive correlations ( P < 0.01) were found between these parameters and the M‐CSF level, but there was no significant correlation between the M‐CSF level and the white blood cell count, serum lipids, or blood pressure. Based on these results, we suggest that an increased M‐CSF level indicates vascular damage or a thrombotic state in patients with an old cerebral infarction. Am. J. Hematol. 60:185–190, 1999. © 1999 Wiley‐Liss, Inc.