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Increased truncated form of plasma tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation
Author(s) -
Shimura Minori,
Wada Hideo,
Nakasaki Takashi,
Hiyoyama Katsuyo,
Mori Yositaka,
Nishikawa Masakatsu,
Deguchi Hiroshi,
Deguchi Katsumi,
Gabazza Esteban C.,
Shiku Hiroshi
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199902)60:2<94::aid-ajh2>3.0.co;2-a
Subject(s) - disseminated intravascular coagulation , tissue factor pathway inhibitor , coagulation , tissue factor , medicine , pathology , gastroenterology
To evaluate that the relationship between the truncated form of tissue factor pathway inhibitor (TFPI) and the stage of disseminated intravascular coagulation (DIC), we measured the plasma levels of tissue factor (TF) antigen and the intact and truncated forms of TFPI antigens in 41 patients with DIC, 12 with pre‐DIC, and 20 with non‐DIC. The plasma TF and total TFPI antigen levels were significantly higher in patients with DIC than in non‐DIC patients. Plasma levels of intact TFPI antigen in the pre‐DIC groups were significantly lower than in the non‐DIC and DIC groups. The truncated form of TFPI antigen levels in DIC patients were significantly increased compared with those in non‐DIC and pre‐DIC patients. The fact that the intact form of TFPI was decreased in pre‐DIC patients compared with that in non‐DIC patients, suggests that it is consumed in the pre‐DIC state and that hypercoagulability occurs in pre‐DIC patients. The increased level of the truncated form of TFPI in DIC patients may be attributed to proteolysis of the intact form of TFPI in these patients. The increased level of the truncated form of TFPI may be a useful index for the diagnosis of DIC. Am. J. Hematol. 60:94–98, 1999. © 1999 Wiley‐Liss, Inc.