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Heterogeneity of clonal development in chronic myeloproliferative disorders
Author(s) -
Ferraris Anna Maria,
Mangerini Rosa,
Racchi Omar,
Rapezzi Davide,
Rolfo Michela,
Casciaro Salvatore,
Gaetani Gian Franco
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199902)60:2<158::aid-ajh14>3.0.co;2-9
Subject(s) - myeloproliferative disorders , clone (java method) , haematopoiesis , biology , chronic myelogenous leukemia , monoclonal , locus (genetics) , polycythemia vera , immunology , leukemia , philadelphia chromosome , genetics , cancer research , monoclonal antibody , chromosomal translocation , stem cell , gene , antibody
Recent reports have suggested a previously unexpected variability in the expression of the dominant neoplastic clone in myeloproliferative disorders (MPD). We evaluated 49 female patients with MPD and informative at the X‐linked androgen receptor (AR) locus to establish the X chromosome inactivation pattern of hemopoietic cells. Whereas in chronic myelogenous leukemia (CML) the granulocytes (PMN) were uniformly of monoclonal origin, a striking heterogeneity of clonal development was found in PMN from patients with other MPD, with up to 50% of them expressing a polyclonal pattern of X inactivation. Am. J. Hematol. 60:158–160, 1999. © 1999 Wiley‐Liss, Inc.