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Severe tumor lysis syndrome following splenic irradiation
Author(s) -
Schifter Theodor,
Cohen Amos,
Lewinski Uri H.
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199901)60:1<75::aid-ajh14>3.0.co;2-2
Subject(s) - tumor lysis syndrome , lysis , medicine , spleen , pathology , immunology , cancer research , chemotherapy
A 72‐year‐old man suffering from non‐Hodgkin's lymphoma is described. After failing to respond to chlorambucil–prednisone regimen for three months, he was treated by splenic irradiation (total dose 500 cGY) in 10 consecutive daily doses. Two days after the last irradiation, the patient developed acute tumor lysis syndrome (TLS) with extreme blood levels of uric acid (33.7 mg/dl), phosphorus (13.7 mg/dl), potassium (6.08 mEq/l), and calcium (6.8 mg/dl). It should be remembered that the acute TLS, which usually occurs following chemotherapy, can also be radiation‐induced. Am. J. Hematol. 60:75–76, 1999. © 1999 Wiley‐Liss, Inc.