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Exclusion of the stomatin, α‐adducin and β‐adducin loci in a large kindred with dehydrated hereditary stomatocytosis
Author(s) -
Innes David Scott,
Sinard John H.,
Gilligan Diana M.,
Snyder L. Michael,
Gallagher Patrick G.,
Morrow Jon S.
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199901)60:1<72::aid-ajh13>3.0.co;2-8
Subject(s) - genotyping , genetics , hereditary spherocytosis , biology , microbiology and biotechnology , polymerase chain reaction , glycophorin , gene , antigen , genotype
Defects in stomatin, α‐and β‐adducin have been implicated in erythrocyte disorders of cation permeability. We performed linkage analysis of the genetic loci for these proteins in a large kindred with xerocytosis (dehydrated hereditary stomatocytosis). Using polymerase chain reaction‐based genotyping techniques, all three loci are excluded as disease gene candidates. Am. J. Hematol. 60:72–74, 1999. © 1999 Wiley‐Liss, Inc.