Premium
Acquired factor VIII inhibitors—successful treatment with an oral outpatient regimen
Author(s) -
Bayer RutheeLu,
Lichtman Stuart M.,
Allen Steven L.,
Budman Daniel R.,
Buchbinder Aby,
Fetten James,
Kolitz Jonathan,
Loscalzo John
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199901)60:1<70::aid-ajh12>3.0.co;2-d
Subject(s) - medicine , regimen , prednisone , coagulopathy , cyclophosphamide , surgery , gastroenterology , chemotherapy
A rare cause of a spontaneous, life threatening coagulopathy in adults is the development of autoantibodies to factor VIII. We recently had the opportunity to treat seven patients with this disorder. After stabilization, they were given a regimen consisting of prednisone and oral cyclophosphamide. All patients had a complete response to treatment. The median time to response was three weeks. Durable remissions were achieved, making this oral regimen an acceptable treatment for this disorder. Am. J. Hematol. 60:70–71, 1999. © 1999 Wiley‐Liss, Inc.