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Factor XI deficiency in women
Author(s) -
Kadir R.A.,
Economides D.L.,
Lee C.A.
Publication year - 1999
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199901)60:1<48::aid-ajh8>3.0.co;2-q
Subject(s) - medicine , coagulopathy , factor xi , pregnancy , hemostasis , gynecology , pediatrics , obstetrics , intensive care medicine , surgery , genetics , biology , coagulation
Abstract Factor XI (FXI) deficiency is an uncommon autosomally transmitted coagulopathy found predominantly in Jewish kindreds. It is associated with variable bleeding tendency that usually manifests after trauma, surgery, or other challenges to hemostasis. Therefore, women with FXI deficiency are at risk of excessive bleeding during their menstrual periods, childbirth, and after surgery. Increased awareness and close collaboration among hematologists, obstetricians, and gynecologists and availability of management guidelines is essential to minimize these risks. This review provides data from current research in FXI deficiency and pregnancy care, menstrual problems, and the role of screening for this disorder in women referred with menorrhagia. Am. J. Hematol. 60:48–54, 1999. © 1999 Wiley‐Liss, Inc.