Premium
Eosinophilia associated with adult t‐cell leukemia: Role of interleukin 5 and granulocyte‐macrophage colony‐stimulating factor
Author(s) -
Ogata Masao,
Ogata Yuko,
Kohno Kazuhiro,
Uno Noritaka,
Ohno Eiji,
Ohtsuka Eiichi,
Saburi Yoshio,
Kamberi Perparim,
Nasu Masaru,
Kikuchi Hiroshi
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199811)59:3<242::aid-ajh11>3.0.co;2-o
Subject(s) - eosinophilia , neutrophilia , eosinophil , granulocyte macrophage colony stimulating factor , immunology , interleukin 5 , interleukin , macrophage , interleukin 3 , medicine , t cell leukemia , granulocyte , leukemia , colony stimulating factor , interleukin 2 , cytokine , in vitro , biology , t cell , haematopoiesis , immune system , antigen presenting cell , stem cell , microbiology and biotechnology , biochemistry , asthma
To clarify the mechanism of eosinophilia in adult T‐cell leukemia (ATL), we studied three ATL patients having marked eosinophilia. Eosinophil‐predominant colony‐stimulating activity was detected in the serum of one patient and in the conditioned media (CM) from cultured ATL cells from two patients. Soluble interleukin 5 (IL‐5), but no interleukin 3 (IL‐3) and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), was detected in sera from all patients. On the other hand, GM‐CSF was produced in vitro by ATL cells from all cases, whereas detectable IL‐3 and IL‐5 was produced by cells from only one, suggesting that in the other two cases, the serum IL‐5 was produced by the normal reacting lymphocytes. The fact that no patient showed marked neutrophilia supports the possibility that IL‐5 may have a leading role in the development of eosinophilia, with GM‐CSF produced by ATL cells playing a complementary role. Am. J. Hematol. 59:242–245, 1998. © 1998 Wiley‐Liss, Inc.