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Pancytopenia due to bone marrow necrosis in acute myelogenous leukemia: Role of reactive CD8 cells
Author(s) -
Markovic S. N.,
Phyliky R. L.,
Li C. Y.
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199809)59:1<74::aid-ajh14>3.0.co;2-1
Subject(s) - pancytopenia , bone marrow , medicine , pathology , necrosis , leukemia , biopsy , immunology
Bone marrow necrosis is a rare clinical condition often associated with hematological malignancy. The mechanism by which malignant disease causes marrow necrosis is unknown. We present a case of a patient with newly diagnosed pancytopenia with bone marrow biopsy evidence of extensive marrow necrosis. Upon further work‐up utilizing Tc bone scan directed bone marrow biopsy, a massive CD8+ T cell marrow infiltrate was discovered engulfing AML‐M2 blasts. The role of Tc bone scans in the work‐up of bone marrow necrosis as well as the potential mechanism of AML‐M2 induced marrow necrosis in the setting of reactive CD8+ T cell infiltration is discussed. Am. J. Hematol. 59:74– 78, 1998. © 1998 Wiley‐Liss, Inc.