Premium
Thrombotic thrombocytopenic purpura associated with HIV and visceral Kaposi's sarcoma treated with plasmapheresis and chemotherapy
Author(s) -
Avery Robert A.,
Denunzio Troy M.,
Craig Daniel B.
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199806)58:2<148::aid-ajh12>3.0.co;2-7
Subject(s) - plasmapheresis , medicine , thrombotic thrombocytopenic purpura , chemotherapy , sarcoma , purpura (gastropod) , surgery , thrombocytopenic purpura , pediatrics , immunology , platelet , pathology , ecology , antibody , biology
We present a case of a patient who is HIV positive and developed both thrombotic thrombocytopenia purpura and visceral Kaposi's sarcoma (KS) with hemorrhage. This case presents a difficult management problem in that the patient's bleeding originated from KS lesions and did not quickly abate with plasmapheresis therapy despite both clinical and laboratory improvement after 2–4 days. Chemotherapy was initiated on day 13 and the patient's condition improved markedly afterward. We believe the addition of chemotherapy to plasmapheresis hastened the improvement of our patient's thrombotic thrombocytopenic purpura (TTP) and KS‐related bleeding. Therefore, under similar conditions, we recommend combining plasmapheresis and chemotherapy at the onset of therapy. Am. J. Hematol. 58:148–149, 1998. Published 1998 Wiley‐Liss, Inc. This article is a U.S. Government work and, as such, is in the public domain in the United States of America.