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Clinical and cytogenetic remission induced by interferon‐α in a patient with chronic eosinophilic leukemia associated with a unique t(3;9;5) translocation
Author(s) -
Yamada Osamu,
Kitahara Kouich,
Imamura Kimiharu,
Ozasa Hisashi,
Okada Michiko,
Mizoguchi Hideaki
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199806)58:2<137::aid-ajh9>3.0.co;2-t
Subject(s) - chromosomal translocation , hypereosinophilia , medicine , pathogenesis , immunology , leukemia , eosinophilia , gastroenterology , biology , gene , genetics
A patient with chronic eosinophilic leukemia and a unique complex chromosomal translocation 46,XY,t(3;9;5)(q25;q34;q33) who had elevated blood interleukin‐5 is reported. Complete cytogenetic remission was induced by interferon‐α after treatment failure with corticosteroids and cytotoxic drugs. Severe cardiopulmonary symptoms due to hypereosinophilia and thromboembolic complication improved dramatically in the first 6 months of interferon therapy. Since it is known that the gene encoding for interleukin‐5 resides on the long arm of chromosome 5, it may be possible that the chromosomal translocation in our patient resulted in overproduction of this cytokine, and our findings may be helpful for understanding the pathogenesis of this disorder. Am. J. Hematol. 58:137–141, 1998. © 1998 Wiley‐Liss, Inc.