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Efficacy and safety of continuous infusion of Mononine® during five surgical procedures in three hemophilic patients
Author(s) -
Ménart Christophe,
Petit Pierre Yves,
Attali Olivier,
Massig Denis,
Dechavanne Marc,
Négrier Claude
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199806)58:2<110::aid-ajh4>3.0.co;2-v
Subject(s) - medicine , continuous infusion , surgery , bolus (digestion) , coagulopathy , complication , anesthesia
We report here five surgeries successfully performed with a continuous infusion of Mononine® (Armour Pharmaceutical Company, Kankakee, IL) in three hemophilic B patients. Before surgery the patients received a bolus dose of 40 to 100 U/kg according to the type of surgery. This injection was followed by a continuous infusion of Mononine®, with an infusion rate of 3.5–7 U/kg/hr in order to maintain a factor IX level between 50 and 100% during the whole surgery and the following 6 days. The infusion rate was further adjusted according to the type of surgery until hospital discharge. This method appears to be safe and efficient, since no abnormal bleeding occurred during surgery and none of the patients presented any thrombotic complication. However, this alternative to intermittent administration of factor IX should be standardized and precisely evaluated, regarding the level and the amount of factor IX required, and the cost of the infused material. In our hands, this cost was decreased by 30–40% compared to previous therapeutic schedules at our institution. Am. J. Hematol. 58:110–116, 1998. © 1998 Wiley‐Liss, Inc.