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Transfusion‐associated graft‐versus‐host disease in immunocompetent patient: Early diagnosis and therapy
Author(s) -
Sakurai Masahiro,
Moizumi Yoshimasa,
Uchida Shigeharu,
Imai Yoshimichi,
Tabayashi Koichi
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199805)58:1<84::aid-ajh17>3.0.co;2-5
Subject(s) - medicine , methylprednisolone , transfusion therapy , disease , graft versus host disease , surgery , blood transfusion
Abstract We report a case of transfusion‐associated graft‐versus‐host disease in a previously healthy, 68‐year‐old Japanese man following an emergency surgery for an acute aortic dissection. We confirmed the chimerism of lymphocytes and the effect of drug therapy using DNA polymorphism analysis. This method is a sensitive, convenient, and rapid method that it is also useful for the evaluation of therapy. And the combination therapy with methylprednisolone, cyclosporine, and 15‐deoxyspergualin may be effective in treating transfusion‐associated GVHD. Am. J. Hematol. 58:84–86, 1998. © 1998 Wiley‐Liss, Inc.