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Transfusion management of an IgA deficient patient with anti‐IgA and incidental correction of IgA deficiency after allogeneic bone marrow transplantation
Author(s) -
Rogers R.L.,
Javed T.A.,
Ross R.E.,
Virella G.,
Stuart R.K.,
FreiLahr D.
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199804)57:4<326::aid-ajh10>3.0.co;2-6
Subject(s) - medicine , iga deficiency , multiple myeloma , immunoglobulin a , bone marrow , immunology , antibody , bone marrow transplantation , blood transfusion , immunopathology , immunoglobulin g
A patient with multiple myeloma was noted to have an IgA deficiency during investigation of a possible transfusion reaction due to IgA deficiency and anti‐IgA. Because of the patient's age, otherwise good health, and early stage of disease, he was enrolled in a research treatment protocol that involved an allogeneic bone marrow transplant (BMT). The BMT successfully put the patient in complete remission from his multiple myeloma and corrected his IgA deficiency. Class‐specific IgG anti‐IgA antibody that had been identified prior to BMT was no longer detectable in his plasma. Anaphylactic transfusion reactions were successfully avoided by using a combination of IgA‐deficient and washed blood components including the marrow graft, and IgA‐reduced intravenous immunoglobulin. Am. J. Hematol. 57:326–330, 1998. © 1998 Wiley‐Liss, Inc.