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Development of rheumatoid arthritis after treatment of large granular lymphocyte leukemia with deoxycoformycin
Author(s) -
Yoe Joe,
Gause Barry L.,
Curti Brendan D.,
Longo Dan L.,
Bagg Adam,
Kopp William C.,
Janik John E.
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199803)57:3<253::aid-ajh14>3.0.co;2-b
Subject(s) - rheumatoid arthritis , medicine , deoxycoformycin , immunology , leukemia , arthritis , neutropenia , chemotherapy , adenosine deaminase , adenosine
The association of T‐cell large granular lymphocyte (LGL) leukemia and rheumatoid arthritis is well described and it is now recognized that these patients and patients with Felty's syndrome represent different aspects of a single disease process. Most patients have rheumatoid arthritis at the time of diagnosis of LGL leukemia. This is the first detailed report of the development of rheumatoid arthritis after the diagnosis and treatment of LGL leukemia as well as the first report of rheumatoid arthritis that occurred in association with deoxycoformycin treatment. It is likely that the beneficial sustained normalization of neutrophil counts as a result of deoxycoformycin treatment played a significant role in the development of this complication. Hematological improvement occurred despite molecular genetic evidence of persistence of the abnormal T‐cell clone. The role of the clonally expanded T cells in the pathogenesis of neutropenia and rheumatoid arthritis is discussed. Am. J. Hematol. 57:253–257, 1998. © 1998 Wiley‐Liss, Inc.