Premium
Deep‐vein thrombosis and coumarin skin necrosis associated with a factor V inhibitor with lupus‐like features
Author(s) -
Kamphuisen Pieter W.,
Haan Joost,
Rosekrans Peter C.M.,
Van Der Meer Felix J.M.
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199802)57:2<176::aid-ajh14>3.0.co;2-a
Subject(s) - coumarin , thrombosis , deep vein , medicine , systemic lupus erythematosus , lupus anticoagulant , necrosis , pathology , chemistry , disease , organic chemistry
We report a 71‐year‐old man who developed deep‐vein thrombosis after major surgery. Coumarin skin necrosis developed after starting oral anticoagulant therapy. An inhibitor to factor V (61 Bethesda units) with lupus‐like features was found as well as a low protein C level. The occurrence of these very rare findings indicates that despite profound procoagulant inhibition (factor V inhibition and anticoagulant therapy), hypercoagulation can occur. Am. J. Hematol. 57:176–178, 1998. © 1998 Wiley‐Liss, Inc.