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Successful treatment of acquired factor VIII inhibitors with cyclosporin
Author(s) -
Brox Alan G.,
Laryea Horace,
Pelletier Marc
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199801)57:1<87::aid-ajh17>3.0.co;2-6
Subject(s) - medicine , bleeding diathesis , gastroenterology , pharmacology , platelet
The treatment of Factor VIII inhibitors remains controversial and no standard therapy exists. We describe in this report two consecutive patients with this inhibitor that responded to cyclosporin. Clinical improvement of the bleeding diathesis, a return to normal of the PTT, a decrease in the level of the inhibitor, and a return to normal of the factor VIII level followed use of this drug. We believe that cyclosporin is effective in the treatment of factor VIII inhibitors and deserves further investigation. Am. J. Hematol. 57:87–88, 1998. © 1998 Wiley‐Liss, Inc.